We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enhanced Effect of Mutant Granulocyte-Colony-Stimulating Factor (KW-2228) on the Growth of Normal and Leukemic Hemopoietic Progenitor Cells in Comparison with Recombinant Human Granulocyte-Colony-Stimulating Factor (G-CSF).
- Authors
Suzuki, Toshiya; Tohda, Shuji; Nagata, Kaoru; Imai, Yasufumi; Murohashi, Ikuo; Nara, Nobuo
- Abstract
We tested the in vitro effect of a novel granulocyte colony-stimulating factor (G-CSF) derivative (KW-2228) on the growth of G-CSF-dependent hemopoietic progenitor cells: granulocyte precursor cells (CFU-G), leukemic blast progenitors freshly obtained from 9 patients with acute myeloblastic leukemia (AML) and cells of a G-CSF-dependent human AML cell line (OCI/AML la). KW-2228 showed a higher stimulating effect than recombinant human G-CSF (rhCSF) on CFU-G; 3 out of 9 leukemic blast progenitors and OCI/AML la cells. The difference in biochemical stability between rhG-CSF and KW-2228 was considered to explain the superior colony-stimulating activity of KW-2228. The results show that KW-2228 will be a new granulopoietic factor. Copyright © 1992 S. Karger AG, Basel
- Publication
Acta Haematologica, 1992, Vol 87, Issue 4, p181
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000204756