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- Title
Toxoplasma gondii infection and abdominal hernia: evidence of a new association.
- Authors
Cosme Alvarado-Esquivel; Sergio Estrada-Martínez
- Abstract
Background: We performed a retrospective, observational study in 1156 adult subjects from the general population of Durango City, Mexico, Fifty five subjects with a history of abdominal hernia repair and 1101 subjects without hernia were examined with enzyme-linked immunoassays for the presence of anti-Toxoplasma IgG and IgM antibodies. Results: The seroprevalence of anti-Toxoplasma IgG antibodies and IgG titers was significantly higher in subjects with abdominal hernia repair than those without hernia. There was a tendency for subjects with hernia repair to have a higher seroprevalence of anti-Toxoplasma IgM antibodies than subjects without hernia. The seroprevalence of anti-Toxoplasma IgG antibodies in subjects with hernia repair was significantly higher in subjects ≥50 years old than those < 50 years old. Further analysis in subjects aged ≥50 years showed that the seroprevalence of anti- Toxoplasma IgG antibodies was also significantly higher in individuals with hernia repair than those without hernia (OR = 2.72; 95% CI: 1.10-6.57). Matching by age and sex further showed that the seroprevalence of Toxoplasma infection was significantly higher in patients with hernia repair than those without hernia (OR: 4.50; 95% CI: 1.22-17.33). Conclusions: Results indicate that infection with Toxoplasma is associated with abdominal hernia. The contributing role of infection with Toxoplasma in abdominal hernia was observed mainly in subjects aged ≥50 years old. Our results might have clinical, prevention and treatment implications and warrant for further investigation.
- Subjects
DURANGO (Durango, Mexico); MEXICO; HERNIA; ENZYME-linked immunosorbent assay; TOXOPLASMA; IMMUNOGLOBULINS
- Publication
Parasites & Vectors, 2011, Vol 4, Issue 1, p112
- ISSN
1756-3305
- Publication type
Article
- DOI
10.1186/1756-3305-4-112