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- Title
Qualitative and quantitative HIV antibodies and viral reservoir size characterization in vertically infected children with virological suppression.
- Authors
Brice, Josephine; Sylla, Mariam; Sayon, Sophie; Telly, Fatoumata; Bocar-Fofana, Djeneba; Murphy, Robert; Lambert-Niclot, Sidonie; Todesco, Eve; Grude, Maxime; Barin, Francis; Diallo, Souleymane; Pillay, Deenan; Derache, Anne; Calvez, Vincent; Marcelin, Anne-Geneviève; Maiga, Almoustapha Issiaka
- Abstract
<bold>Background: </bold>Absence of detectable viraemia after treatment cessation in some vertically HIV-infected (VHIV) children suggests that early initiation of HAART could lead to functional cure.<bold>Objectives: </bold>We described the factors associated with HIV antibody levels and the viral reservoir size in HAART-treated VHIV children.<bold>Methods: </bold>Study included 97 VHIV children with virological suppression, in Bamako, Mali. The anti-gp41 antibody activities and HIV serostatus were assessed. The viral reservoir size was measured by quantifying total cell-associated HIV DNA.<bold>Results: </bold>Among the children studied, the median total HIV DNA level was 445 copies/10 6 cells (IQR = 187-914) and the median anti-gp41 antibody activity was 0.29 OD (IQR = 0.18-0.75). Low activity of anti-gp41 antibodies was associated with a younger age of HAART initiation ( P = 0.01). Overall, eight HIV-1 seroreversions were identified.<bold>Conclusions: </bold>Study identified potential candidates with low viral reservoir and low antibody levels or activities for future trials aiming to reduce HIV-1 reservoir to limit HAART duration.
- Subjects
HIV antibodies; HIV-positive persons; IMMUNOSUPPRESSION; PATIENT acceptance of health care; HEALTH outcome assessment; HIV infection transmission; ANTI-HIV agents; HIV; HIV infections; LONGITUDINAL method; RESEARCH funding; VIRAL antibodies; VIRAL load; HIGHLY active antiretroviral therapy; CROSS-sectional method; VERTICAL transmission (Communicable diseases); VIREMIA; PHYSIOLOGY
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2017, Vol 72, Issue 4, p1147
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkw537