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- Title
A study to Assess the Effects of Antiperspirant Aluminium Nitrate on the Rabbit Skin.
- Authors
Rashid, Mubeen; Gupta, Sangeeta
- Abstract
This present study was aimed to observe under the research grade compound light microscope the histo-toxicological effects manifested post-application of 10% and 20% solutions of aluminium nitrate that was topically applied onto the outermost surface of the ear integument of 24 Albino rabbits treated daily. The animals were then divided into two groups comprising of 12 experimental and 12 controls. Initially right sided test areas were excised of the experimental and control animals after 15 days of application to observe immediate effects, whereas the left sided test areas of the animals were kept for another month without any further treatment and then excised on day 45 to elucidate its delayed effects. The results revealed histological features of a thickened epidermis with hyperkeratosis, acanthosis and the presence of epidermal micro-abscesses. The dermis showed features of edema, increase in vascularity, decrease in sweat and sebaceous glands and infiltration of inflammatory cells. It was significantly noted that the histological features were far more severely manifested in the integument applied with 20% w/v solution as compared to that applied with 10% w/v solution. However these changes persisted in a moderate form following discontinuation of aluminium nitrate application.
- Subjects
ALUMINUM; ANTIPERSPIRANTS; SWEAT glands; SEBACEOUS glands; NITRATES
- Publication
JK Science, 2019, Vol 21, Issue 2, p88
- ISSN
0972-1177
- Publication type
Article