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- Title
Mycobacterium tuberculosis Microbiologic and Clinical Treatment Outcomes in a Randomized Trial of Immediate versus CD4<sup>+</sup>-Initiated Antiretroviral Therapy in HIV-Infected Adults with a High CD4<sup>+</sup> Cell Count.
- Authors
Chamie, Gabriel; Charlebois, Edwin D.; Srikantiah, Padmini; Walusimbi-Nanteza, Maria; Mugerwa, Roy D.; Mayanja, Harriet; Okwera, Alphonse; Whalen, Christopher C.; Havlir, Diane V.
- Abstract
In a prospective randomized, controlled trial in Uganda comparing the efficacy of antiretroviral therapy during tuberculosis therapy with the efficacy of tuberculosis therapy alone in HIV-infected patients with tuberculosis who have a CD4+ cell count 1350 cells/mL, it was found that antiretroviral therapy did not accelerate microbiologic, radiographic, or clinical responses to tuberculosis therapy: 18% of participants had sputum smears positive for Mycobacterium tuberculosis after 5 months of tuberculosis therapy, despite having had negative culture results.
- Subjects
UGANDA; ANTIRETROVIRAL agents; TUBERCULOSIS treatment; HIV-positive persons; MYCOBACTERIUM tuberculosis; CD4 antigen; BACTERIAL cultures; SPUTUM microbiology; CLINICAL trials
- Publication
Clinical Infectious Diseases, 2010, Vol 51, Issue 3, p359
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/654799