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- Title
rhBMP-2 in an injectable Gelfoam carrier enhances consolidation of the distracted callus in a sheep model.
- Authors
Floerkemeier, Thilo; Thorey, Fritz; Wellmann, Mathias; Hurschler, Christof; Budde, Stefan; Windhagen, Henning; Floerkemeier, T; Thorey, F; Wellmann, M; Hurschler, C; Budde, S; Windhagen, H
- Abstract
<bold>Background: </bold>A major problem associated with distraction osteogenesis is the long time required for consolidation.<bold>Objective: </bold>The goal of this study was to determine whether a percutaneous injection of recombinant human bone morphogenetic protein-2 (rhBMP-2) in a Gelfoam carrier would enhance bone consolidation following distraction.<bold>Methods: </bold>A unilateral tibial osteotomy combined with external stabilization was performed in 14 adult sheep. After a latency of four days, distraction was performed at 1.25 millimetres per day for 20 days. On days 23 and 30, the sheep received an injection of rhBMP-2/Gelfoam or buffer/Gelfoam. During the following 50 days, radiographs and in vivo torsional stiffness measurements were obtained weekly. The effect of rhBMP-2 treatment post-mortem was assessed using destructive biomechanical testing, quantitative CT and DXA analysis.<bold>Results: </bold>The in vivo stiffness measurements of the sheep treated with rhBMP-2 were significantly higher than those of the carrier control group (p< 0.05). These in vivo data were verified by post-mortem biomechanical testing and quantitative CT analysis. The maximum torsional moment observed was 55% greater in the sheep treated with rhBMP-2.<bold>Conclusions: </bold>These data support the potential use of rhBMP-2 in an injectable carrier for enhancing consolidation, as it may ultimately lead to shorter treatment times for patients undergoing distraction procedures.
- Subjects
BONE morphogenetic proteins; CALLUS; BONE growth; OSTEOTOMY; GROWTH factors; ANIMAL experimentation; ANIMALS; BONE lengthening (Orthopedics); COMPUTED tomography; KINEMATICS; RECOMBINANT proteins; SHEEP; TIBIA; BONE density; SURGICAL sponges
- Publication
Technology & Health Care, 2017, Vol 25, Issue 6, p1163
- ISSN
0928-7329
- Publication type
journal article
- DOI
10.3233/THC-170944