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- Title
Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration
- Authors
Li, Yonghe; Lu, Wenyan; Bu, Guojun
- Abstract
The low density lipoprotein receptor-related protein (LRP) is a multifunctional cell surface receptor highly expressed in human aortic smooth muscle cells. In the present study, we used the short interfering RNA (siRNA) technique to explore the role of LRP in smooth muscle cell migration. We identified an LRP-specific siRNA that selective silences LRP expression in human aortic smooth muscle cells. As a consequence, LRP-mediated ligand degradation was significantly reduced. More important, we found that platelet-derived growth factor-dependent cell migration was inhibited in cells transfected with LRP siRNA. These results demonstrate an important role of LRP in smooth muscle cell migration.
- Subjects
LIPOPROTEINS; CELL membranes; AORTA; SMOOTH muscle; MUSCLE cells
- Publication
FEBS Letters, 2003, Vol 555, Issue 2, p346
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(03)01272-9