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- Title
Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation
- Authors
Yang, Shi Yu; Goldspink, Geoffrey
- Abstract
The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.
- Subjects
SOMATOMEDIN; CELL proliferation; PEPTIDES
- Publication
FEBS Letters, 2002, Vol 522, Issue 1-3, p156
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02918-6