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- Title
A single dose vaccination with an elastase-dependent H1N1 live attenuated swine influenza virus protects pigs from challenge with 2009 pandemic H1N1 virus.
- Authors
Mašić, Aleksandar; Woldeab, Niziti; Embury-Hyatt, Carissa; Zhou, Yan; Babiuk, Shawn
- Abstract
The 2009 outbreak of H1N1 influenza A viruses in humans underscored the importance of pigs in influenza A virus evolution and the emergence of novel viruses with pandemic potential. In addition, influenza A virus infections continued to cause production losses in the agricultural industry resulting in a significant drop of profit. The primary method to control influenza A virus infections in pigs is through vaccination. Previously we demonstrated that two doses of an elastase-dependent live attenuated swine influenza virus administered by either the intratracheal or intranasal route can provide a high degree of protection in pigs against challenge with both homologous and different heterologous swine influenza viruses. Here we report the protection efficacy of a single dose elastase-dependent live attenuated swine influenza virus administered by the intranasal route against challenge with homologous subtypic H1N1 2009 pandemic swine-like influenza virus. Protection was observed in the absence of neutralizing antibodies specific for H1N1 2009 in sera.
- Subjects
ELASTASES; INFLUENZA A virus, H1N1 subtype; AGRICULTURAL industries; IMMUNOGLOBULINS; SWINE influenza; VIRUS diseases; VACCINATION
- Publication
Acta Veterinaria, 2014, Vol 64, Issue 1, p10
- ISSN
0567-8315
- Publication type
Article
- DOI
10.2478/acve-2014-0002