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Study to evaluate the optimal dose of remifentanil required to ensure apnea during magnetic resonance imaging of the heart under general anesthesia.
- Published in:
- Pediatric Anesthesia, 2021, v. 31, n. 5, p. 548, doi. 10.1111/pan.14164
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- Publication type:
- Article
Principles of dose finding studies in cancer: a comparison of trial designs.
- Published in:
- Cancer Chemotherapy & Pharmacology, 2013, v. 71, n. 5, p. 1107, doi. 10.1007/s00280-012-2059-8
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- Publication type:
- Article
What is the expected benefit of patient-centric clinical development in oncology?
- Published in:
- Journal of Biopharmaceutical Statistics, 2022, v. 32, n. 3, p. 414, doi. 10.1080/10543406.2022.2065506
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- Publication type:
- Article
A comparison of stochastic programming methods for portfolio level decision-making.
- Published in:
- Journal of Biopharmaceutical Statistics, 2020, v. 30, n. 3, p. 405, doi. 10.1080/10543406.2019.1684307
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- Publication type:
- Article
Randomized dose-escalation designs for drug combination cancer trials with immunotherapy.
- Published in:
- Journal of Biopharmaceutical Statistics, 2019, v. 29, n. 2, p. 359, doi. 10.1080/10543406.2018.1535503
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- Publication type:
- Article
Model selection based on combined penalties for biomarker identification.
- Published in:
- Journal of Biopharmaceutical Statistics, 2018, v. 28, n. 4, p. 735, doi. 10.1080/10543406.2017.1378662
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- Publication type:
- Article
Repeated measures regression mixture models.
- Published in:
- Behavior Research Methods, 2020, v. 52, n. 2, p. 591, doi. 10.3758/s13428-019-01257-7
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- Publication type:
- Article
Impact of an equality constraint on the class-specific residual variances in regression mixtures: A Monte Carlo simulation study.
- Published in:
- Behavior Research Methods, 2016, v. 48, n. 2, p. 813, doi. 10.3758/s13428-015-0618-8
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- Publication type:
- Article
Development of consensus-driven SPIRIT and CONSORT extensions for early phase dose-finding trials: the DEFINE study.
- Published in:
- BMC Medicine, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12916-023-02937-0
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- Publication type:
- Article
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic.
- Published in:
- 2022
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- Publication type:
- journal article
Individual differences in the effects of the ACTION-PAC intervention: an application of personalized medicine in the prevention and treatment of obesity.
- Published in:
- Journal of Behavioral Medicine, 2022, v. 45, n. 2, p. 211, doi. 10.1007/s10865-021-00274-2
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- Publication type:
- Article
Reducing intrusive memories after trauma via an imagery-competing task intervention in COVID-19 intensive care staff: a randomised controlled trial.
- Published in:
- Translational Psychiatry, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41398-023-02578-0
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- Publication type:
- Article
Recurrent events modelling of haemophilia bleeding events.
- Published in:
- Journal of the Royal Statistical Society: Series C (Applied Statistics), 2021, v. 70, n. 2, p. 351, doi. 10.1111/rssc.12462
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- Publication type:
- Article
Subgroup analysis of treatment effects for misclassified biomarkers with time‐to‐event data.
- Published in:
- Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68, n. 5, p. 1447, doi. 10.1111/rssc.12364
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- Publication type:
- Article
An information theoretic phase I–II design for molecularly targeted agents that does not require an assumption of monotonicity.
- Published in:
- Journal of the Royal Statistical Society: Series C (Applied Statistics), 2019, v. 68, n. 2, p. 347, doi. 10.1111/rssc.12293
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- Publication type:
- Article
Exploring the issues that influence how people with rare neurological conditions engage in physical activity.
- Published in:
- Disability & Rehabilitation, 2024, v. 46, n. 13, p. 2789, doi. 10.1080/09638288.2023.2230128
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- Publication type:
- Article
Optimal design for multi-arm multi-stage clinical trials.
- Published in:
- 2011
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- Publication type:
- Abstract
Improving safety of the continual reassessment method via a modified allocation rule.
- Published in:
- 2019
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- Publication type:
- journal article
An alternative method to analyse the biomarker-strategy design.
- Published in:
- 2018
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- Publication type:
- journal article
Design and estimation in clinical trials with subpopulation selection.
- Published in:
- 2018
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- Publication type:
- journal article
Simultaneous confidence regions for multivariate bioequivalence.
- Published in:
- Statistics in Medicine, 2017, v. 36, n. 29, p. 4585, doi. 10.1002/sim.7446
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- Publication type:
- Article
Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters.
- Published in:
- 2017
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- Publication type:
- journal article
Estimation in multi-arm two-stage trials with treatment selection and time-to-event endpoint.
- Published in:
- 2017
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- Publication type:
- journal article
Simultaneous confidence regions for multivariate bioequivalence.
- Published in:
- 2017
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- Publication type:
- journal article
Factorial versus multi-arm multi-stage designs for clinical trials with multiple treatments.
- Published in:
- 2017
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- Publication type:
- journal article
Asymmetric inner wedge group sequential tests with applications to verifying whether effective drug concentrations are similar in adults and children.
- Published in:
- 2017
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- Publication type:
- journal article
Designing multi-arm multi-stage clinical trials using a risk-benefit criterion for treatment selection.
- Published in:
- 2016
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- Publication type:
- journal article
A practical design for a dual-agent dose-escalation trial that incorporates pharmacokinetic data.
- Published in:
- Statistics in Medicine, 2015, v. 34, n. 13, p. 2138, doi. 10.1002/sim.6482
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- Publication type:
- Article
Authors' reply to Comments on 'Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs'.
- Published in:
- Statistics in Medicine, 2013, v. 32, n. 30, p. 5487, doi. 10.1002/sim.6000
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- Publication type:
- Article
Estimation in AB/BA crossover trials with application to bioequivalence studies with incomplete and complete data designs.
- Published in:
- Statistics in Medicine, 2013, v. 32, n. 30, p. 5469, doi. 10.1002/sim.5886
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- Publication type:
- Article
Planning multi-arm screening studies within the context of a drug development program.
- Published in:
- Statistics in Medicine, 2013, v. 32, n. 20, p. 3424, doi. 10.1002/sim.5787
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- Publication type:
- Article
Analysing malaria drug trials on a per-individual or per-clone basis: a comparison of methods.
- Published in:
- 2013
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- Publication type:
- journal article
Analysing malaria drug trials on a per-individual or per-clone basis: a comparison of methods.
- Published in:
- Statistics in Medicine, 2013, v. 32, n. 17, p. 3020, doi. 10.1002/sim.5706
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- Publication type:
- Article
Designing exploratory cancer trials using change in tumour size as primary endpoint.
- Published in:
- Statistics in Medicine, 2013, v. 32, n. 15, p. 2544, doi. 10.1002/sim.5716
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- Publication type:
- Article
Optimal design of multi-arm multi-stage trials.
- Published in:
- Statistics in Medicine, 2012, v. 31, n. 30, p. 4269, doi. 10.1002/sim.5513
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- Publication type:
- Article
A novel Phase I/IIa design for early phase oncology studies and its application in the evaluation of MK-0752 in pancreatic cancer.
- Published in:
- Statistics in Medicine, 2012, v. 31, n. 18, p. 1931, doi. 10.1002/sim.5331
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- Publication type:
- Article
Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs.
- Published in:
- Statistics in Medicine, 2012, v. 31, n. 11/12, p. 1059, doi. 10.1002/sim.4386
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- Publication type:
- Article
Costs and staffing resource requirements for adaptive clinical trials: quantitative and qualitative results from the Costing Adaptive Trials project.
- Published in:
- 2021
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- Publication type:
- journal article
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs.
- Published in:
- 2020
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- Publication type:
- journal article
Multi-arm multi-stage trials can improve the efficiency of finding effective treatments for stroke: a case study.
- Published in:
- 2018
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- Publication type:
- journal article
Statistical evaluation of toxicological assays: Dunnett or Williams test-take both.
- Published in:
- Archives of Toxicology, 2013, v. 87, n. 11, p. 1901, doi. 10.1007/s00204-013-1065-x
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- Publication type:
- Article
Author Correction: A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.
- Published in:
- 2020
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- Publication type:
- Correction Notice
A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58790-1
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- Publication type:
- Article
A randomised controlled trial of rosuvastatin for the prevention of aminoglycoside-induced kidney toxicity in children with cystic fibrosis.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-58790-1
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- Publication type:
- Article
Clinical Drug Development in Epilepsy Revisited: A Proposal for a New Paradigm Streamlined Using Extrapolation.
- Published in:
- 2016
- By:
- Publication type:
- journal article
Correction: Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing
- Published in:
- 2023
- By:
- Publication type:
- Correction Notice
Medicines and Healthcare products Regulatory Agency's "Consultation on proposals for legislative changes for clinical trials": a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing.
- Published in:
- Trials, 2023, v. 24, n. 1, p. 1, doi. 10.1186/s13063-023-07763-6
- By:
- Publication type:
- Article
A seamless Phase I/II platform design with a time-to-event efficacy endpoint for potential COVID-19 therapies.
- Published in:
- Statistical Methods in Medical Research, 2024, v. 33, n. 11/12, p. 2115, doi. 10.1177/09622802241288348
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- Publication type:
- Article
Adaptive enrichment trial designs using joint modelling of longitudinal and time-to-event data.
- Published in:
- Statistical Methods in Medical Research, 2024, v. 33, n. 11/12, p. 2098, doi. 10.1177/09622802241287711
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- Publication type:
- Article
A comparison of model-free phase I dose escalation designs for dual-agent combination therapies.
- Published in:
- Statistical Methods in Medical Research, 2024, v. 33, n. 2, p. 203, doi. 10.1177/09622802231220497
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- Publication type:
- Article