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- Title
Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device.
- Authors
Kim, Jaehoon; Yoon, Junghyo; Byun, Jae-Yeong; Kim, Hyunho; Han, Sewoon; Kim, Junghyun; Lee, Jeong Hoon; Jo, Han-Sang; Chung, Seok; Torralba Silgado, Antonio Jesus
- Abstract
Blood plasma is a source of biomarkers in blood and a simple, fast, and easy extraction method is highly required for point-of-care testing (POCT) applications. This paper proposes a membrane filter integrated microfluidic device to extract blood plasma from whole blood, without any external instrumentation. A commercially available membrane filter was integrated with a newly designed dual-cover microfluidic device to avoid leakage of the extracted plasma and remaining blood cells. Nano-interstices installed on both sides of the microfluidic channels actively draw the extracted plasma from the membrane. The developed device successfully supplied 20 μL of extracted plasma with a high extraction yield (~45%) in 16 min.
- Subjects
MICROFLUIDIC devices; MEMBRANE filters; BLOOD cells; BLOOD plasma; PLASMA sources; POINT-of-care testing
- Publication
Sensors (14248220), 2021, Vol 21, Issue 4, p1366
- ISSN
1424-8220
- Publication type
Article
- DOI
10.3390/s21041366