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- Title
Histocompatibility Antigens in Primary Biliary Cirrhosis.
- Authors
Johnston, David E.; Kaplan, Marshall M.; Miller, Kenneth B.; Connors, Christine M.; Milford, Edgar L.
- Abstract
HLA-A, -B, and -DR antigens were examined in 71 patients with primary biliary cirrhosis (PBC) enrolled in a randomized, double-blind trial of colchicine versus placebo. All patients had typical laboratory and histological features of PBC, except that six had a negative test for antimitochondrial antibody. Frequencies of these antigens were compared with the international Caucasian panel of the Eighth International Workshop and with a local Caucasian panel. Antigen frequencies were compared using the <em>x</em>² test, with a correction for the number of antigens tested. The PBC patients had a significant excess of DR4 (29 of 70 typed, or 41.1 %) compared to the international (804 of 3811, or 21.1%, corrected <em>p</em> value <0.05) but not the local panel (47 or 129, or 36.4%). Of PBC patients, 52.9% had only one DR antigen identified, compared to 67.5% for the international panel and 49.6% for the local panel. In past studies, the HLA antigen most strongly correlated with PBC was DR8, but this was not included in our panel of antisera. However, no significant relationship between HLA and PBC was found among the antigens screened.
- Subjects
HLA histocompatibility antigens; CIRRHOSIS of the liver; COLCHICINE; IMMUNOGLOBULINS; PATIENTS
- Publication
American Journal of Gastroenterology (Springer Nature), 1987, Vol 82, Issue 11, p1127
- ISSN
0002-9270
- Publication type
Article