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- Title
Cerebrospinal fluid real-time quaking-induced conversion is a robust and reliable test for sporadic creutzfeldt-jakob disease: An international study.
- Authors
McGuire, Lynne I.; Poleggi, Anna; Poggiolini, Ilaria; Suardi, Silvia; Grznarova, Katarina; Shi, Song; de Vil, Bart; Sarros, Shannon; Satoh, Katsuya; Cheng, Keding; Cramm, Maria; Fairfoul, Graham; Schmitz, Matthias; Zerr, Inga; Cras, Patrick; Equestre, Michele; Tagliavini, Fabrizio; Atarashi, Ryuichiro; Knox, David; Collins, Steven
- Abstract
Real-time quaking-induced conversion (RT-QuIC) has been proposed as a sensitive diagnostic test for sporadic Creutzfeldt-Jakob disease; however, before this assay can be introduced into clinical practice, its reliability and reproducibility need to be demonstrated. Two international ring trials were undertaken in which a set of 25 cerebrospinal fluid samples were analyzed by a total of 11 different centers using a range of recombinant prion protein substrates and instrumentation. The results show almost complete concordance between the centers and demonstrate that RT-QuIC is a suitably reliable and robust technique for clinical practice. Ann Neurol 2016;80:160-165.
- Subjects
CREUTZFELDT-Jakob disease diagnosis; COMPARATIVE studies; CREUTZFELDT-Jakob disease; INTERNATIONAL relations; RESEARCH methodology; MEDICAL cooperation; PRIONS; RECOMBINANT proteins; RESEARCH; RESEARCH evaluation; RESEARCH funding; EVALUATION research; CASE-control method
- Publication
Annals of Neurology, 2016, Vol 80, Issue 1, p160
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.24679