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- Title
Metabolic Syndrome at Follow-Up in Women with Prior Gestational Diabetes and Its Association with Abnormal Glucose Tolerance and Family History of Type 2 DM.
- Authors
Albarran, Olga Gonzalez; Roldan, Cecilia; Lahera, Marcos; Aragón, Carmen; Sanchón, Raúl; Sancho, José M.
- Abstract
Women with prior gestational diabetes (GDM) have an increased risk of later DM-2, cardiovascular risk factors and probably cardiovascular events. The aims of the present study were to evaluate the prevalence of abnormal glucose tolerance and metabolic syndrome (MS) in a cohort of women with prevoius GDM, and their relationships with insulin resistance and family history of DM-2. We prospectively studied 198 women with GDM, at 12 month follow - up after deliver. Body mass index (BMI), waist circumference (WC), blood pressure (BP), lipid profile, microalbuminuria, HbA1c were performed. According to 75g oral glucose tolerance test (OGTT), women were divided into two groups: GDM with normal glucose tolerance post-partum (NG) and GDM with abnormal glucose tolerance post-partum (AG). MS was defined by IDF criteria and insulin resistance by HOMA. Mean age was 33,45 ± 4,5 yrs.; 26,25% smoking, 15,6% history of dyslipemia, 30% had history of previous abortions. 62,34% of women had first-degree relatives with DM-2 and 59,25% had family history of hypertension and 18.4% of CAD. 66,8% of GDM had AG and 33,2% presented NG (p<0.001). The prevalence of MS was higher (32,3%) in AG group than in NG group (14,7 %); p<0.001. In addition, AG group had higher values of BMI (28,86 ± 4,5 Kg/m² ) and WC (93,76 ± 6,1 cm) than NG group (22,70 ± 3,1 Kg/m², p<0.005 and 80,34 ± 4,6; p<0.05, respectively). Fasting glucose and 2h-glucose levels were higher in AG group than NG (98,85 ± 7,7 vs 80,2 ±5,6 mg/dl, p<0.005 and 166,57 ± 23 vs 119,4 ± 20 mg/dl, p<0.005). HOMA was higher in AG than NG; p<0.005. Microalbuminuria levels showed a tendency to higher values in AG than NG (p=0.06). Moreover, AG group showed a higher family history of DM-2(68,7% vs 48%, p<0.01) and hypertension (65,7% vs 39%, p<0.05).WC correlated with abnormalities in OGTT (r=0.6; p<0.05) and MS (0.48; p<0.05). In conclusion, women with GDM have a high prevalence of abnormal glucose tolerance and MS. Obesity and family history of DM-2 are the main predictors of MS in women with DGM, specially in AG group. Thus these women may be especially suitable interventions aimed at preventing or reducing DM-2 and probably cardiovascular events.
- Subjects
METABOLIC syndrome; DIABETES in women; BLOOD sugar; TYPE 2 diabetes; INSULIN resistance; OBESITY
- Publication
Diabetes, 2007, Vol 56, pA706
- ISSN
0012-1797
- Publication type
Article