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- Title
Mechanotransduction Circuits in Human Pathobiology.
- Authors
Gargalionis, Antonios N.; Papavassiliou, Kostas A.; Papavassiliou, Athanasios G.
- Abstract
This document, titled "Mechanotransduction Circuits in Human Pathobiology," discusses the importance of mechanical forces in maintaining cellular and tissue homeostasis in the human body. It explains how cells sense and respond to various mechanical forces, such as fluid shear stress, hydrostatic pressure, tensile forces, and compressive forces. The process through which cells convert these mechanical forces into cellular responses is called mechanotransduction. The document also explores the role of mechanotransduction in various diseases, including congenital heart disease, atherosclerosis, osteoarthritis, and cancer. Additionally, it discusses the potential therapeutic applications of targeting mechanosensitive molecules in the treatment of diseases.
- Subjects
MECHANOTRANSDUCTION (Cytology); ION channels; TISSUE differentiation; FOCAL adhesion kinase; EXTRACELLULAR matrix; CELL migration
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 7, p3816
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25073816