We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Does Hypertension Affect the Recovery of Renal Functions after Reversal of Unilateral Ureteric Obstruction?
- Authors
Hammad, Fayez T.; Lubbad, Loay; Al-Salam, Suhail; Hammad, Waheed F.; Yasin, Javed; Meeran, Mohamed Fizur Nagoor; Ojha, Shreesh; Arunachalam, Seenipandi; Hammad, Awwab F.
- Abstract
Research has demonstrated that hypertension can lead to an exaggeration in the renal functional and histological changes caused by ureteral obstruction. These changes were particularly observed shortly after the release of a relatively brief period of unilateral ureteral obstruction (UUO). However, the long-term impact of hypertension on the recovery of renal functions has not been investigated beyond the immediate period after UUO reversal. In order to investigate this effect, a group of spontaneously hypertensive rats (G-SHR, n = 11) and a group of normotensive Wistar Kyoto rats (G-NTR, n = 11) were subjected to a 48 h reversible left UUO. The impact of UUO was then examined 45 days after the reversal of obstruction. The glomerular filtration rate, renal blood flow, and the fractional excretion of sodium in the post-obstructed left kidney (POK) showed similarities to the non-obstructed right kidney (NOK) in both groups. However, the changes in the albumin creatinine ratio, renal injury markers, pro-apoptotic markers, and histological changes in the G-SHR were much more pronounced compared to the G-NTR. We conclude that hypertension continues to have a significant impact on various aspects of renal injury and function, even several weeks after UUO reversal.
- Subjects
URETERIC obstruction; SUGAMMADEX; GLOMERULAR filtration rate; BLOOD flow; HYPERTENSION; LABORATORY rats
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 3, p1540
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25031540