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- Title
NLRP3 Inflammasome as a Potential Therapeutic Target in Dry Eye Disease.
- Authors
Zhuang, Dian; Misra, Stuti L.; Mugisho, Odunayo O.; Rupenthal, Ilva D.; Craig, Jennifer P.
- Abstract
Dry eye disease (DED) is a multifactorial ocular surface disorder arising from numerous interrelated underlying pathologies that trigger a self-perpetuating cycle of instability, hyperosmolarity, and ocular surface damage. Associated ocular discomfort and visual disturbance contribute negatively to quality of life. Ocular surface inflammation has been increasingly recognised as playing a key role in the pathophysiology of chronic DED. Current readily available anti-inflammatory agents successfully relieve symptoms, but often without addressing the underlying pathophysiological mechanism. The NOD-like receptor protein-3 (NLRP3) inflammasome pathway has recently been implicated as a key driver of ocular surface inflammation, as reported in pre-clinical and clinical studies of DED. This review discusses the intimate relationship between DED and inflammation, highlights the involvement of the inflammasome in the development of DED, describes existing anti-inflammatory therapies and their limitations, and evaluates the potential of the inflammasome in the context of the existing anti-inflammatory therapeutic landscape as a therapeutic target for effective treatment of the disease.
- Subjects
DRY eye syndromes; NLRP3 protein; INFLAMMASOMES; EYE inflammation; THERAPEUTICS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 13, p10866
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241310866