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- Title
IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis.
- Authors
Wu, Tsung-Ju; Chang, Sunny Li-Yun; Lin, Chih-Yang; Lai, Chao-Yang; He, Xiu-Yuan; Tsai, Chun-Hao; Ko, Chih-Yuan; Fong, Yi-Chin; Su, Chen-Ming; Tang, Chih-Hsin
- Abstract
Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocytes into the inflamed joint synovium. Interleukin (IL)-17 is a critical inflammatory mediator that participates in the progression of OA, although the mechanisms linking IL-17 and monocyte infiltration are not well understood. Our analysis of synovial tissue samples retrieved from the Gene Expression Omnibus (GEO) dataset exhibited higher monocyte marker (CD11b) and vascular cell adhesion molecule 1 (VCAM-1) levels in OA samples than in normal, healthy samples. The stimulation of human OA synovial fibroblasts (OASFs) with IL-17 increased VCAM-1 production and subsequently enhanced monocyte adhesion. IL-17 affected VCAM-1-dependent monocyte adhesion by reducing miR-5701 expression through the protein kinase C (PKC)-α and c-Jun N-terminal kinase (JNK) signaling cascades. Our findings improve our understanding about the effect of IL-17 on OA progression and, in particular, VCAM-1 production and monocyte adhesion, which may help with the design of more effective OA treatments.
- Subjects
INTERLEUKIN-17; CELL adhesion molecules; FIBROBLASTS; PROTEIN kinase C; CELL adhesion; INFLAMMATORY mediators; OSTEOARTHRITIS; MONOCYTES
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 12, p6804
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23126804