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- Title
Protein-Mediated Transformations of Superparamagnetic Nanoparticles Evidenced by Single-Particle Inductively Coupled Plasma Tandem Mass Spectrometry: A Disaggregation Phenomenon.
- Authors
Sikorski, Jacek; Matczuk, Magdalena; Kamińska, Agnieszka; Kruszewska, Joanna; Trzaskowski, Maciej; Timerbaev, Andrei R.; Jarosz, Maciej
- Abstract
Progress toward translating superparamagnetic iron oxide nanoparticles (SPIONs) with specific diagnostic and therapeutic properties for clinical applications depends on developing and implementing appropriate methodologies that would allow in-depth characterizations of their behavior in a real biological environment. Herein, we report a versatile approach for studying interactions between SPIONs and proteins using single-particle inductively coupled plasma tandem mass spectrometry. By monitoring the changes in the size distribution upon exposure to human serum, the formation of stable protein corona is revealed, accompanied by particle disaggregation.
- Subjects
INDUCTIVELY coupled plasma mass spectrometry; TANDEM mass spectrometry; IRON oxide nanoparticles; NANOPARTICLES
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 3, p1088
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23031088