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- Title
Iron Availability in Tissue Microenvironment: The Key Role of Ferroportin.
- Authors
Gammella, Elena; Correnti, Margherita; Cairo, Gaetano; Recalcati, Stefania; Musci, Giovanni; Bonaccorsi Di Patti, Maria Carmela
- Abstract
Body iron levels are regulated by hepcidin, a liver-derived peptide that exerts its function by controlling the presence of ferroportin (FPN), the sole cellular iron exporter, on the cell surface. Hepcidin binding leads to FPN internalization and degradation, thereby inhibiting iron release, in particular from iron-absorbing duodenal cells and macrophages involved in iron recycling. Disruption in this regulatory mechanism results in a variety of disorders associated with iron-deficiency or overload. In recent years, increasing evidence has emerged to indicate that, in addition to its role in systemic iron metabolism, FPN may play an important function in local iron control, such that its dysregulation may lead to tissue damage despite unaltered systemic iron homeostasis. In this review, we focus on recent discoveries to discuss the role of FPN-mediated iron export in the microenvironment under both physiological and pathological conditions.
- Subjects
IRON; IRON in the body; IRON metabolism; HEPCIDIN; TISSUES
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 6, p2986
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22062986