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- Title
Mitochondrial Homeostasis Mediates Lipotoxicity in the Failing Myocardium.
- Authors
Kretzschmar, Tom; Wu, Jasmine M. F.; Schulze, P. Christian; Lazou, Antigone
- Abstract
Heart failure remains the most common cause of death in the industrialized world. In spite of new therapeutic interventions that are constantly being developed, it is still not possible to completely protect against heart failure development and progression. This shows how much more research is necessary to understand the underlying mechanisms of this process. In this review, we give a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression. In particular, we focus on the regulation of fatty acid metabolism and the effects of fatty acid accumulation on mitochondrial structural and functional homeostasis.
- Subjects
HOMEOSTASIS; MITOCHONDRIA; HEART failure; FATTY acids; METABOLISM; MYOCARDIUM
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 3, p1498
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22031498