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- Title
Diagnostic and Therapeutic Implications of microRNAs in Non-Small Cell Lung Cancer.
- Authors
Ahn, Young-Ho; Ko, Yoon Ho
- Abstract
microRNAs (miRNAs), endogenous suppressors of target mRNAs, are deeply involved in every step of non-small cell lung cancer (NSCLC) development, from tumor initiation to progression and metastasis. They play roles in cell proliferation, apoptosis, angiogenesis, epithelial-to-mesenchymal transition, migration, invasion, and metastatic colonization, as well as immunosuppression. Due to their versatility, numerous attempts have been made to use miRNAs for clinical applications. miRNAs can be used as cancer subtype classifiers, diagnostic markers, drug-response predictors, prognostic markers, and therapeutic targets in NSCLC. Many challenges remain ahead of their actual clinical application; however, when achieved, the use of miRNAs in the clinic is expected to enable great progress in the diagnosis and treatment of patients with NSCLC.
- Subjects
NON-small-cell lung carcinoma; MICRORNA; EPITHELIAL-mesenchymal transition
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 22, p8782
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21228782