We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer.
- Authors
Quanxia Lv; Ziyuan Meng; Yuanyuan Yu; Feng Jiang; Daogang Guan; Chao Liang; Junwei Zhou; Aiping Lu; Ge Zhang
- Abstract
Breast cancer is the second leading cause of cancer death among women. Human epidermal receptor 2 (HER2) positive breast cancer (HER2+ BC) is the most aggressive subtype of breast cancer, with poor prognosis and a high rate of recurrence. About one third of breast cancer is HER2+ BC with significantly high expression level of HER2 protein compared to other subtypes. Therefore, HER2 is an important biomarker and an ideal target for developing therapeutic strategies for the treatment HER2+ BC. In this review, HER2 structure and physiological and pathological roles in HER2+ BC are discussed. Two diagnostic tests, immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH), for evaluating HER2 expression levels are briefly introduced. The current mainstay targeted therapies for HER2+ BC include monoclonal antibodies, small molecule tyrosine kinase inhibitors, antibody-drug conjugates (ADC) and other emerging anti-HER2 agents. In clinical practice, combination therapies are commonly adopted in order to achieve synergistic drug response. This review will help to better understand the molecular mechanism of HER2+ BC and further facilitate the development of more effective therapeutic strategies against HER2+ BC.
- Subjects
BREAST cancer patients; CANCER-related mortality; DISEASES in women; EPIDERMAL cyst; IMMUNOHISTOCHEMISTRY techniques; CANCER treatment
- Publication
International Journal of Molecular Sciences, 2016, Vol 17, Issue 12, p2095
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms17122095