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- Title
The Potential of Adaptive Design in Animal Studies.
- Authors
Majid, Arshad; Ok-Nam Bae; Redgrave, Jessica; Teare, Dawn; Ali, Ali; Zemke, Daniel
- Abstract
Clinical trials are the backbone of medical research, and are often the last step in the development of new therapies for use in patients. Prior to human testing, however, preclinical studies using animal subjects are usually performed in order to provide initial data on the safety and effectiveness of prospective treatments. These studies can be costly and time consuming, and may also raise concerns about the ethical treatment of animals when potentially harmful procedures are involved. Adaptive design is a process by which the methods used in a study may be altered while it is being conducted in response to preliminary data or other new information. Adaptive design has been shown to be useful in reducing the time and costs associated with clinical trials, and may provide similar benefits in preclinical animal studies. The purpose of this review is to summarize various aspects of adaptive design and evaluate its potential for use in preclinical research.
- Subjects
EXPERIMENTAL design; CLINICAL trials; DRUG development; ANIMAL models in research; ETHICS; LABORATORY animals
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 10, p24048
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms161024048