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- Title
Prognostic significance of serum osteopontin levels in small cell lung cancer.
- Authors
Xu, Chunhua; Yuan, Qi; Wang, Wei; Chi, Chuanzhen; Zhang, Qian; Li, Li; Yang, Rusong; Wang, Yuchao
- Abstract
<bold>Background: </bold>Osteopontin (OPN) is closely related to tumor occurrence and metastasis. This study explored the clinical value of serum OPN levels in small cell lung cancer (SCLC) patients.<bold>Methods: </bold>The ELISA method was used to determine the OPN level of 96 SCLC patients before and after first-line chemotherapy, and compared with 60 healthy controls.<bold>Results: </bold>The serum OPN level of SCLC patients before treatment was significantly higher than that of the healthy control (P < 0.001). Serum OPN levels were related to disease stage, tumor size, and lymph node metastasis (P = 0.012, 0.034, and 0.037, respectively). Serum OPN level decreased after first-line chemotherapy (P = 0.019), which was related to treatment response (P = 0.011). The serum OPN level was an independent predictor of overall survival.<bold>Conclusions: </bold>The serum OPN level can be used as a biomarker to predict treatment response and survival of SCLC patients.
- Subjects
SMALL cell lung cancer; SERUM
- Publication
BMC Pulmonary Medicine, 2020, Vol 20, Issue 1, pN.PAG
- ISSN
1471-2466
- Publication type
journal article
- DOI
10.1186/s12890-020-01242-3