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- Title
Mondia whitei (Periplocaceae) prevents and Guibourtia tessmannii (Caesalpiniaceae) facilitates fictive ejaculation in spinal male rats.
- Authors
Watcho, Pierre; Deeh Defo, Patrick Brice; Wankeu-Nya, Modeste; Carro-Juarez, Miguel; Nguelefack, Telesphore Benoît; Kamanyi, Albert
- Abstract
Background: Mondia whitei and Guibourtia tessmannii are used in Cameroon traditional medicine as aphrodisiacs. The present study was undertaken to evaluate the pro-ejaculatory effects of the aqueous and organic solvent extracts of these plants in spinal male rats. Methods: In spinal cord transected and urethane-anesthetized rats, two electrodes where inserted into the bulbospongiosus muscles and the ejaculatory motor pattern was recorded on a polygraph after urethral and penile stimulations, intravenous injection of saline (0.1 ml/100 g), dopamine (0.1 μM/kg), aqueous and organic solvent plant extracts (20 mg/kg). Results: In all spinal rats, urethral and penile stimulations always induced the ejaculatory motor pattern. Aqueous or hexane extract of Mondia whitei (20 mg/kg) prevented the expression of the ejaculatory motor pattern. The pro-ejaculatory effects of dopamine (0.1 μM/kg) were not abolished in spinal rats pre-treated with Mondia whitei extracts. Aqueous and methanolic stem bark extracts of Guibourtia tessmannii (20 mg/kg) induced fictive ejaculation characterized by rhythmic contractions of the bulbospongiosus muscles followed sometimes with expulsion of seminal plugs. In rats pre-treated with haloperidol (0.26 μM/kg), no ejaculatory motor pattern was recorded after intravenous injection of Guibourtia tessmannii extracts (20 mg/kg). Conclusion: These results show that Mondia whitei possesses preventive effects on the expression of fictive ejaculation in spinal male rats, which is not mediated through dopaminergic pathway; on the contrary, the pro-ejaculatory activities of Guibourtia tessmannii require the integrity of dopaminergic system to exert its effects. The present findings further justify the ethno-medicinal claims of Mondia whitei and Guibourtia tessmannii.
- Subjects
ANALYSIS of variance; ANIMAL experimentation; BARK; DOPAMINE; EJACULATION; ELECTROMYOGRAPHY; INTRAVENOUS injections; MEDICINAL plants; PHYSIOLOGIC salines; RATS; RESEARCH funding; PLANT roots; SOLVENTS; SPINAL cord; STATISTICS; TRADITIONAL medicine; PHYTOCHEMICALS; PLANT extracts; DATA analysis; HALOPERIDOL; DATA analysis software
- Publication
BMC Complementary & Alternative Medicine, 2013, Vol 13, Issue 1, p1
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/1472-6882-13-4