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- Title
Factor H and CFHR1 polymorphisms associated with atypical Haemolytic Uraemic Syndrome (aHUS) are differently expressed in Tunisian and in Caucasian populations.
- Authors
Leban, N.; Abarrategui-Garrido, C.; Fariza-Requejo, E.; Amiñoso-Carbonero, C.; Pinto, S.; Chibani, J. B.; Khelil, A. H.; Sánchez-Corral, P.
- Abstract
Summary Several polymorphisms in the complement components factor H and CFHR1 are associated with higher risk to develop atypical Haemolytic Uraemic Syndrome (aHUS) in Caucasians. We have determined the prevalence of these polymorphisms in Tunisian controls by using genetic and immunological techniques. No differences in the frequency of the factor H risk alleles c.−331C>T, c.2089A>G or c.2881G>T between Tunisian and Caucasians were found. On the contrary, the analysis of CFHR1 polymorphism revealed a higher frequency of Tunisian individuals homozygous for the CFHR1* Del (deleted) allele, and of individuals presenting the CFHR1*A phenotype. These results suggest distinct contributions of factor H and CFHR1 polymorphisms to aHUS in Tunisian and Caucasian populations.
- Subjects
TUNISIA; CAUCASUS; GENETIC polymorphisms; UREMIA; GENE frequency
- Publication
International Journal of Immunogenetics, 2012, Vol 39, Issue 2, p110
- ISSN
1744-3121
- Publication type
Article
- DOI
10.1111/j.1744-313X.2011.01071.x