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- Title
Short-term and long-term epidemiological impacts of sustained vector control in various dengue endemic settings: A modelling study.
- Authors
Sun, Haoyang; Koo, Joel; Dickens, Borame L.; Clapham, Hannah E.; Cook, Alex R.
- Abstract
As the most widespread viral infection transmitted by the Aedes mosquitoes, dengue has been estimated to cause 51 million febrile disease cases globally each year. Although sustained vector control remains key to reducing the burden of dengue, current understanding of the key factors that explain the observed variation in the short- and long-term vector control effectiveness across different transmission settings remains limited. We used a detailed individual-based model to simulate dengue transmission with and without sustained vector control over a 30-year time frame, under different transmission scenarios. Vector control effectiveness was derived for different time windows within the 30-year intervention period. We then used the extreme gradient boosting algorithm to predict the effectiveness of vector control given the simulation parameters, and the resulting machine learning model was interpreted using Shapley Additive Explanations. According to our simulation outputs, dengue transmission would be nearly eliminated during the early stage of sustained and intensive vector control, but over time incidence would gradually bounce back to the pre-intervention level unless the intervention is implemented at a very high level of intensity. The time point at which intervention ceases to be effective is strongly influenced not only by the intensity of vector control, but also by the pre-intervention transmission intensity and the individual-level heterogeneity in biting risk. Moreover, the impact of many transmission model parameters on the intervention effectiveness is shown to be modified by the intensity of vector control, as well as to vary over time. Our study has identified some of the critical drivers for the difference in the time-varying effectiveness of sustained vector control across different dengue endemic settings, and the insights obtained will be useful to inform future model-based studies that seek to predict the impact of dengue vector control in their local contexts. Author summary: Sustained vector control remains key to reducing the global burden of dengue. However, current understanding of the main drivers for the differences in the time-varying epidemiological impact of dengue vector control across different transmission settings remains limited. We developed an agent-based model and showed that in the absence of a highly effective intervention technology that is able to eliminate dengue transmission even in an entirely susceptible population, a fixed level of reduction in the Aedes abundance would only cause temporary reduction in dengue incidence. Furthermore, the time point at which intervention ceases to be effective is strongly influenced not only by the intensity of vector control and the pre-intervention transmission intensity, but also by the individual-level heterogeneity in biting risk. Besides, the intensity of vector control interacts with the other two factors mentioned earlier, and the interaction magnitude also changes over time. These insights will be useful to inform future modelling studies that seek to predict the impact of Aedes control on dengue transmission in their local contexts, and have important implications for the design of intervention strategies to achieve sustained reduction in the global burden of dengue.
- Subjects
VECTOR control; ARBOVIRUS diseases; DENGUE; BOOSTING algorithms; VIRUS diseases; MACHINE learning
- Publication
PLoS Computational Biology, 2022, Vol 18, Issue 4, p1
- ISSN
1553-734X
- Publication type
Article
- DOI
10.1371/journal.pcbi.1009979