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- Title
Polycyclic N-Heterocyclic Compounds. Part 84: Reaction of N-(pyrido[3′,2′:4,5]thieno[3,2- d]pyrimidin-4-yl)amidines or N-(pyrido[2′,3′:4,5]furo[3,2- d]pyrimidin-4-yl)amidines with Hydroxylamine Hydrochloride.
- Authors
Okuda, Kensuke; Ide, Ryota; Uramaru, Naoto; Hirota, Takashi
- Abstract
The reactions of nine N-(pyrido[3′,2′:4,5]thieno[3,2- d]pyrimidin-4-yl)amidines ( 3) with hydroxylamine hydrochloride produced new products. These were formed via of the pyrimidine component followed by a 1,2,4-oxadiazole-forming ring closure to give N-[2-([1,2,4]oxadiazol-5-yl)thieno[2,3- b]pyridin-3-yl]formamide oximes ( 11). Reaction of six N-(pyrido[2′,3′:4,5]furo[3,2- d]pyrimidin-4-yl)amidines ( 12) with hydroxylamine hydrochloride gave similar results. Effects of the newly synthesized compounds on pentosidine formation were also evaluated.
- Subjects
POLYCYCLIC compounds; HETEROCYCLIC compounds; PYRIMIDINES; AMIDINES; HYDROXYLAMINE hydrochloride; OXADIAZOLES
- Publication
Journal of Heterocyclic Chemistry, 2015, Vol 52, Issue 3, p880
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.2033