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- Title
Convenient synthesis of substituted 2-(2-iminocoumarin-3-yl)thieno[2,3-d]pyrimidin-4-ones.
- Authors
Shynkarenko, Pavlo E.; Vlasov, Sergiy V.; Kovalenko, Sergiy M.; Shishkina, Svitlana V.; Shishkin, Oleg V.; Chernykh, Valentin P.
- Abstract
<GRAPHIC></GRAPHIC> The interaction of both 2-iminocoumarin-3-carbonitriles and 2-iminocoumarin-3-carbothioamides with 2-aminothiophen-3-carboxamides lead to formation of 3-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)-2-iminocoumarins in two steps. The simplicity of the procedure, as well as the high yields of the target products make this method to be a good alternative of Knoevenagel condensation for the synthesis of 3-(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)-2-iminocoumarins. J. Heterocyclic Chem., (2010).
- Subjects
PYRIMIDINES; CONDENSATION; ACETIC acid; PHARMACOLOGY; NUCLEAR magnetic resonance spectroscopy; X-ray diffraction
- Publication
Journal of Heterocyclic Chemistry, 2010, Vol 47, Issue 4, p800
- ISSN
0022-152X
- Publication type
Article
- DOI
10.1002/jhet.219