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- Title
d-Amino acids in the brain: pyridoxal phosphate-dependent amino acid racemases and the physiology ofd-serine.
- Authors
Rodríguez-Crespo, Ignacio
- Abstract
The article analyzes the physiology of D-serine in the brain particularly the localization and regulation of brain serine racemase both in neurotransmission and in neurodegeneration. It describes how pyridoxal phosphate-dependent enzymes perform the racemization reaction. It explores the regulation of serine racemase by divalent cations, nucleotides and interacting proteins.
- Subjects
PHYSIOLOGY; SERINE; AMINO acids; NEURAL transmission; GLYCINE; NEURODEGENERATION; VITAMIN B6; ENZYMES
- Publication
FEBS Journal, 2008, Vol 275, Issue 14, p3513
- ISSN
1742-464X
- Publication type
Article
- DOI
10.1111/j.1742-4658.2008.06514.x