We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Multiple arterial‐phase MRI with gadoxetic acid improves diagnosis of hepatocellular carcinoma ≤3.0 cm.
- Authors
Hong, Seung Baek; Hong, Sun; Choi, Sang Hyun; Park, Seo Young; Shim, Ju Hyun; Kim, So Yeon; Lee, Seung Soo; Kim, Suk
- Abstract
Background and Aims: Multiple arterial‐phase magnetic resonance imaging (MA‐MRI) was introduced to overcome the limitations of gadoxetic acid‐enhanced MRI, but its clinical impacts on hepatocellular carcinoma (HCC) diagnosis have not been well assessed. We investigated whether MA‐MRI with gadoxetic acid could improve the diagnosis of HCC ≤3.0 cm in comparison with single arterial‐phase MRI (SA‐MRI). Methods: This retrospective study included 397 patients from two tertiary institutions who underwent gadoxetic acid‐enhanced MRI (243 patients with 271 lesions in cohort‐1 underwent SA‐MRI, and 154 patients with 166 lesions in cohort‐2 underwent MA‐MRI). The patients had 437 hepatic lesions ≤3.0 cm with pathologic confirmation. The arterial‐phase image quality and diagnostic performance of SA‐MRI and MA‐MRI were analysed and compared. To minimize the effects of selection bias because of potential confounding between the two groups, propensity score‐matching was additionally performed. Results: MA‐MRI showed a significantly higher percentage of optimal arterial‐phase timing (94.2% vs. 74.5%, p <.001) and lower incidence of inadequate examinations (1.3% vs. 5.8%, p =.034) than SA‐MRI. MA‐MRI had a significantly higher non‐rim arterial‐phase hyperenhancement (APHE) detection rate (94.9% vs. 85.5%, p =.005) and sensitivity for diagnosing HCC (87.4% vs. 70.0%, p <.001) than SA‐MRI, but no significant difference in specificity (92.9% vs. 93.1%, p =.966). In 123 pairs of propensity score‐matched patients, MA‐MRI had significantly higher sensitivity (89.1% vs. 74.5%, p =.006) than SA‐MRI with equal specificity (92.3% vs. 92.3%, p >.999). Conclusions: Compared with SA‐MRI, MA‐MRI with gadoxetic acid can detect more non‐rim APHE and significantly improve sensitivity for diagnosing HCC ≤3.0 cm, without a significant decrease in specificity.
- Subjects
HEPATOCELLULAR carcinoma; MAGNETIC resonance imaging; DIAGNOSTIC imaging
- Publication
Liver International, 2023, Vol 43, Issue 2, p462
- ISSN
1478-3223
- Publication type
Article
- DOI
10.1111/liv.15470