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- Title
Chromosome end protection becomes even more complex.
- Authors
Karlseder, Jan
- Abstract
The article discusses the result of the study which suggests that a single telomere that is recognized as DNA damage is not sufficient to trigger cell cycle arrest. Individual deprotected telomeres were examined through combining analysis of metaphase spreading, immunofluorescence-based detection of telomere-induced damage foci, and chromosome-orientation fluorescence in situ hybridization. Telomeres in ALT-positive cells that were found attached to damage markers were also investigated.
- Subjects
TELOMERES; DNA; CELL death; FLUORESCENCE in situ hybridization; CELL cycle regulation; GENETICS
- Publication
Nature Structural & Molecular Biology, 2009, Vol 16, Issue 12, p1205
- ISSN
1545-9993
- Publication type
Article
- DOI
10.1038/nsmb1209-1205