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- Title
Transition Metal-Free Synthesis of 3-Alkynylpyrrole-2-carboxylates via Michael Addition/Intramolecular Cyclodehydration.
- Authors
Teng, Qing ‐ hu; Xu, Yan ‐ li; Liang, Ying; Wang, Heng ‐ shan; Wang, Ying ‐ chun; Pan, Ying ‐ ming
- Abstract
A transition metal-free and efficient method for the synthesis of 3-alkynylpyrrole-2-carboxylates from diynones and glycine esters or 2-aminoacetophenone hydrochloride has been developed. This transformation provides a large range of substituted pyrroles in good to excellent yields with the elimination of water as the only by-product. The detailed mechanistic studies elucidated that this transformation involves a Michael addition/intramolecular cyclodehydration process.
- Subjects
CARBOXYLATES; MICHAEL reaction; INTRAMOLECULAR catalysis; PYRROLES; HETEROCYCLIC compounds
- Publication
Advanced Synthesis & Catalysis, 2016, Vol 358, Issue 12, p1897
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201501073