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- Title
An Improved Synthesis of Imidazo[4,5- b]pyridines and Imidazo[4,5- b]pyrazines by Palladium Catalyzed Amidation using Xantphos in a 1,4-Dioxane: tert-Amyl Alcohol Solvent System.
- Authors
Rosenberg, Adam J.; Ahmed, Ijaz; Wilson, Robert J.; Williams, Theresa M.; Kaminsky, Lauren; Clark, Daniel A.
- Abstract
Herein an improved protocol for the synthesis of imidazo[4,5- b]pyridines and imidazo[4,5- b]pyrazines using a palladium-catalyzed amidation that utilizes Xantphos as an ancillary phosphine ligand is reported. The use of a binary solvent system comprised of 1,4-dioxane and tert-amyl alcohol was crucial in eliminating unwanted by-products.
- Subjects
CHEMICAL synthesis; PALLADIUM catalysts; AMIDATION; PHOSPHINE; PYRIDINE; PYRAZINES; CATALYSIS
- Publication
Advanced Synthesis & Catalysis, 2014, Vol 356, Issue 16, p3465
- ISSN
1615-4150
- Publication type
Other
- DOI
10.1002/adsc.201400465