We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Significant heterogeneity in the geographical distribution of diffuse grade II/III gliomas in France.
- Authors
Darlix, Amélie; Zouaoui, Sonia; Virion, Jean-Marc; Rigau, Valérie; Mathieu-Daudé, Hélène; Blonski, Marie; Reyes-Botero, German; Bessaoud, Faiza; Trétarre, Brigitte; Bauchet, Fabienne; Capelle, Laurent; Fabbro, Michel; Kerr, Christine; Figarella-Branger, Dominique; Duffau, Hugues; Taillandier, Luc; Bauchet, Luc
- Abstract
Diffuse WHO grade II and III gliomas (DGII/IIIG) are rare tumors, with few specific epidemiological studies. We aimed at describing the geographical distribution of a homogeneous series of histologically confirmed DGII/IIIG, over a four-year period (2006-2009), at a national level. The methodology is based on a multidisciplinary national network already established by the French Brain Tumor DataBase and data collected directly from every neuropathology department. Personal home addresses were collected for confirmed cases. For each region, the incidence of DGII/IIIG was analyzed and standardized on the age and sex distribution of the French population. The number of patients with newly diagnosed, histologically confirmed DGII/IIIG was 4,790. The overall crude rate was 19.4/10. To enable international comparisons, standardized rates were calculated as follows: 19.8/10, 18.8/10 and 16.0/10 (reference population, Europe, US and world, respectively). The geographical distribution by region showed significant differences, with higher incidence rates in Northeast and central parts of France. This work is the first studying the geographical distribution of a pure series of DGII/IIIG at a national level. It demonstrates significant heterogeneity in the distribution, and raises the question of the role of environmental and/or genetic risk(s) factor(s) for DGII/IIIG.
- Subjects
FRANCE; GLIOMAS; BRAIN tumors; MEDICAL databases; WORLD Health Organization; EPIDEMIOLOGY; NEUROLOGICAL disorders
- Publication
Journal of Neuro-Oncology, 2014, Vol 120, Issue 3, p547
- ISSN
0167-594X
- Publication type
Article
- DOI
10.1007/s11060-014-1585-0