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- Title
Accessory pathway location affects brain natriuretic peptide level in patients with Wolff-Parkinson-White syndrome.
- Authors
Nakatani, Yosuke; Kumagai, Koji; Naito, Shigeto; Nakamura, Kohki; Minami, Kentaro; Nakano, Masahiro; Sasaki, Takehito; Kinugawa, Koichiro; Oshima, Shigeru
- Abstract
<bold>Purpose: </bold>The purpose of this study was to investigate the relationship between the accessory pathway location and brain natriuretic peptide (BNP) level in patients with Wolff-Parkinson-White (WPW) syndrome.<bold>Methods: </bold>We divided 102 WPW syndrome patients with normal left ventricular systolic function into four groups: those with manifest right (MR, n = 14), manifest septal (MS, n = 11), manifest left (ML, n = 30), and concealed (C, n = 47) accessory pathways. BNP level and electrophysiological properties, including difference in timing of the ventricular electrogram between the His bundle area and the distal coronary sinus area (His-CS delay), which indicate intraventricular dyssynchrony, were compared.<bold>Results: </bold>BNP levels (pg/dl) were higher in the MR and MS groups than in the ML and C groups (MR, 64 ± 58; MS, 55 ± 45; ML, 17 ± 15; C, 25 ± 21; P < 0.001). AV intervals (ms) were shorter in the MR and MS groups than in the ML and C groups (MR, 76 ± 16; MS, 83 ± 6; ML, 101 ± 19; C, 136 ± 20; P < 0.001). His-CS delay (ms) was longer in the MR group than in the other groups (MR, 50 ± 15; MS, 21 ± 7; ML, 23 ± 10; C, 19 ± 8; P < 0.001). The AV interval (P < 0.01) and the His-CS delay (P < 0.001) were negatively and positively correlated, respectively, with the BNP level.<bold>Conclusion: </bold>Anterograde conduction with a right or septal accessory pathway increased the BNP level in WPW syndrome patients with normal cardiac function.
- Subjects
BRAIN natriuretic factor; HEART hormones; WOLFF-Parkinson-White syndrome; ARRHYTHMIA; ELECTROSURGERY; HEART diseases; THERAPEUTICS; ELECTROCARDIOGRAPHY; HEART ventricle diseases; PEPTIDE hormones; RESEARCH evaluation; DIAGNOSIS
- Publication
Journal of Interventional Cardiac Electrophysiology, 2017, Vol 48, Issue 1, p81
- ISSN
1383-875X
- Publication type
journal article
- DOI
10.1007/s10840-016-0205-7