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- Title
The.
- Authors
Chen, Jin Hui; Wang, Hui Li; Guo, Bao Yuan; Xu, Peng; Li, Jian Zhong
- Abstract
ABSTRACT The pharmacokinetics of diniconazole enantiomers in quail ( Coturnix coturnix japonica) were investigated by liquid chromatography-tandem (LC-MS/MS). Quails were exposed to racemic diniconazole in capsule by oral at dose of 10 mg/kg (body weight). The maximal concentrations observed in blood, heart, liver, and kidney were 3.18, 11.35, 12.32, 15.03 µg/g for S-diniconazole, and 1.13, 3.70, 6.00, 2.60 µg/g for R-diniconazole. The elimination of enantiomers all met the one-compartment model in blood, heart, liver, and kidney well. The elimination half-lives (T1/2) of S-diniconazole were 2.87, 3.85, 5.29, and 4.42 h in blood, heart, liver, and kidney, respectively; the T1/2 of R-diniconazole were 2.44, 3.42, 146.23, and 74.02 h in blood, heart, liver, and kidney, respectively. The enantiomer fractions (EFs) steadily increased from 0.50 to 0.92 in blood samples and 0.91 in heart samples. Meanwhile, the values increased to 0.70 and 0.80 in liver and kidney initially, and then decreased to 0.33 and 0.44 at the end of the experiment. Metabolism was examined as well and it was found that diniconazole was metabolized to 1, 2, 4-triazole, (E)-3-(1H-1, 2, 4-triazol-1-yl) acrylaldehyde, (E, S)-(R, S)-4-(2, 4-dichlorophenyl)-2, 2-dimethyl-5-(1H-1, 2, 4-triazol-1-yl) pent-4-ene-1, 3-diol, (E)-4-(2, 4-dichlorophenyl)-3-hydroxy-2, 2-dimethyl-5-(1H-1, 2, 4-triazol-1-yl) pent-4-enoic acid, and 1, 3-dichlorobenzen in all samples of quail. Chirality 25:910-916, 2013. © 2013 Wiley Periodicals, Inc.
- Subjects
JAPANESE quail; DINICONAZOLE; ENANTIOMERS; PHARMACOKINETICS; ENANTIOSELECTIVE catalysis; RACEMIC mixtures
- Publication
Chirality, 2013, Vol 25, Issue 12, p910
- ISSN
0899-0042
- Publication type
Article
- DOI
10.1002/chir.22233