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- Title
Biology of Bone Sarcomas and New Therapeutic Developments.
- Authors
Brown, Hannah K.; Schiavone, Kristina; Gouin, François; Heymann, Marie-Françoise; Heymann, Dominique
- Abstract
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis. This review gives a brief overview of their specificities and summarises the main therapeutic advances in the field of bone sarcoma.
- Subjects
SARCOMA; BONE metastasis; BONE cancer; TUMORS; IMMUNOTHERAPY; BONE tumors; CELL physiology; GIANT cell tumors
- Publication
Calcified Tissue International, 2018, Vol 102, Issue 2, p174
- ISSN
0171-967X
- Publication type
journal article
- DOI
10.1007/s00223-017-0372-2