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- Title
MHC class I A region diversity and polymorphism in macaque species.
- Authors
Otting, Nel; De Vos-Rouweler, Annemiek J. M.; Heijmans, Corrine M. C.; De Groot, Natasja G.; Doxiadis, Gaby G. M.; Bontrop, Ronald E.
- Abstract
The HLA-A locus represents a single copy gene that displays abundant allelic polymorphism in the human population, whereas, in contrast, a nonhuman primate species such as the rhesus macaque ( Macaca mulatta) possesses multiple HLA-A-like ( Mamu-A) genes, which parade varying degrees of polymorphism. The number and combination of transcribed Mamu-A genes present per chromosome display diversity in a population of Indian animals. At present, it is not clearly understood whether these different A region configurations are evolutionarily stable entities. To shed light on this issue, rhesus macaques from a Chinese population and a panel of cynomolgus monkeys (Macaca fascicularis) were screened for various A region-linked variations. Comparisons demonstrated that most A region configurations are old entities predating macaque speciation, whereas most allelic variation (>95%) is of more recent origin. The latter situation contrasts the observations of the major histocompatibility complex class II genes in rhesus and cynomolgus macaques, which share a high number of identical alleles (>30%) as defined by exon 2 sequencing.
- Subjects
GENETIC polymorphisms; HLA histocompatibility antigens; RHESUS monkeys; KRA; CERCOPITHECIDAE; TRANSPLANTATION immunology
- Publication
Immunogenetics, 2007, Vol 59, Issue 5, p367
- ISSN
0093-7711
- Publication type
Article
- DOI
10.1007/s00251-007-0201-2