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- Title
Structural elucidation and nuclear magnetic resonance spectral assignments of five new compounds from Paraconiothyrium brasiliense.
- Authors
Li, Hui; Chen, Lian; Xiong, Xiao‐Xiao; Yang, Hui‐Shu; Xu, Bang; Liu, Cheng‐Xiong; Zou, Kun
- Abstract
In this paper, 11 compounds with five new compounds were isolated by silica gel column chromatography and repeated HPLC, and their structural characteristics were determined by NMR, high resolution mass spectrometry (HR-MS), X-ray, and circular dichroism/electronic circular dichroism (CD/ECD) data analyses. The isolated compounds were screened for antiplatelet aggregation activity, where Compounds 3-5 and 7-10 exhibited different degrees of activities with inhibition of 0.7%-15.91%, and among them, Compound 3 showed better inhibitory activity than the antiplatelet drug aspirin. Compared with Compound 1, the SP 13 sp C-NMR spectra of Compound 3 had two fewer hydroxyl carbon signals, but there were two additional olefinic carbon signals at SB C sb 149.2 (C-11) and SB C sb 109.9 ppm (C-13) in Compound 3 versus Compound 1. Compared with Compound 1, the SP 13 sp C-NMR spectra of Compound 2 were basically consistent, but the SP 1 sp H-NMR spectra had subtle differences at H-6, H-7, H-8, and H-13; therefore, we speculated that there was a configuration difference at C-7 or C-11 between Compounds 2 and Compound 1.
- Subjects
NUCLEAR magnetic resonance; ASPIRIN; OVERHAUSER effect (Nuclear physics); CHEMICAL formulas; BERBERINE; METHOXY group; NORMAL-phase chromatography
- Publication
Magnetic Resonance in Chemistry, 2023, Vol 61, Issue 3, p184
- ISSN
0749-1581
- Publication type
Article
- DOI
10.1002/mrc.5322