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- Title
C-proSP-B: A Possible Biomarker for Pulmonary Diseases?
- Authors
Kahn, Nicolas; Rossler, Anne-Kathrin; Hornemann, Katrin; Muley, Thomas; Grünig, Ekkehard; Schmidt, Werner; Herth, Felix J.F.; Kreuter, Michael
- Abstract
<bold>Background:</bold> Detection of surfactant proteins A and D (SP-A and SP-D) in the serum of patients with pulmonary diseases is thought to reflect an injury of the alveolar epithelial barrier and as such serve as a biomarker for these diseases. However, the data for SP-B are limited. <bold>Objectives:</bold> The aim of this feasibility study was to assess whether immature SP-B pre-proteins might have value as a possible biomarker for pulmonary diseases. <bold>Methods:</bold> In serum samples from patients with different chronic lung diseases (interstitial lung diseases [ILDs], chronic obstructive pulmonary disease, asthma, lung cancer, pulmonary hypertension, inflammation, patients on ventilator support; total n = 283), C-proSP-B was measured using an electrochemiluminescence immunoassay based on mouse monoclonal anti-C-proSP-B antibodies. Levels were correlated to lung functional and clinical parameters. <bold>Results:</bold> The highest C-proSP-B levels were detected in the serum of idiopathic pulmonary fibrosis (IPF) patients. In a multivariate analysis, C-proSP-B levels were able to discriminate IPF patients from patients with all other pulmonary diseases (p < 0.0001). No significant correlations were found between C-proSP-B levels and lung function, smoking history, or disease extent. <bold>Conclusions:</bold> SP-B pre-proteins might serve as a biomarker in pulmonary diseases with alveolar or interstitial damage such as ILDs, especially in IPF. Their role in the long-term monitoring of such diseases has to be clarified further.
- Subjects
ASTHMA diagnosis; INTERSTITIAL lung diseases; LUNG disease diagnosis; OBSTRUCTIVE lung disease diagnosis; LUNG physiology; LUNG tumors; PULMONARY hypertension diagnosis; INFLAMMATION; BIOMARKERS; IMMUNOASSAY; MONOCLONAL antibodies; MULTIVARIATE analysis; PATIENTS; PULMONARY surfactant; SMOKING; MECHANICAL ventilators; PILOT projects; DISEASE progression; IDIOPATHIC pulmonary fibrosis; DIAGNOSIS
- Publication
Respiration, 2018, Vol 96, Issue 2, p117
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000488245