We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Efficacy of the Simeox ® Airway Clearance Technology in the Homecare Treatment of Children with Clinically Stable Cystic Fibrosis: A Randomized Controlled Trial.
- Authors
Sands, Dorota; Walicka-Serzysko, Katarzyna; Milczewska, Justyna; Postek, Magdalena; Jeneralska, Natalia; Cichocka, Aleksandra; Siedlecka, Ewa; Borawska-Kowalczyk, Urszula; Morin, Laurent
- Abstract
Background: Cystic fibrosis (CF) patients require regular airway clearance therapy (ACT). The aim of this study was to evaluate homecare therapeutic effects of a new ACT (Simeox®) added to the optimal standard of care, including home chest physiotherapy, in the treatment of clinically stable children. Methods: Forty pediatric CF patients (8–17 years old) with stable disease were randomized 1:1 in a single-center, prospective, open-label, cross-over trial into two groups: with or without Simeox®. Lung function (impulse oscillometry, spirometry, body plethysmography, multi-breath nitrogen washout) results, health-related quality of life, and safety were assessed during the study after 1 month of therapy at home. Results: A significant decrease in proximal airway obstruction (as supported by improvement in airway resistance at 20 Hz (R20Hz) and maximum expiratory flow at 75% of FVC (MEF75)) compared to the control group was observed after 1 month of therapy with the device. Lung-clearance index was stable in the study group, while it worsened in the control group. In addition, the device group demonstrated a significant increase in the Cystic Fibrosis Questionnaire—Revised (CFQ-R) physical score. No side effects were identified during the study. Conclusions: Simeox® may improve drainage of the airways in children with clinically stable CF and could be an option in chronic treatment of the disease.
- Subjects
CYSTIC fibrosis treatment; AIRWAY (Anatomy); HOME care services; TREATMENT effectiveness; RANDOMIZED controlled trials; RESEARCH funding; PULMONARY function tests; STATISTICAL sampling
- Publication
Children, 2023, Vol 10, Issue 2, p204
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children10020204