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- Title
Tumor Suppressor in Lung Cancer-1 Is a Prognostic Predictor for the Recurrence and Progression of Non-Muscle-Invasive Bladder Cancer.
- Authors
Chen, Yegang; Yang, Yongjiao; Liu, Li; Wang, Shangren; Song, Hong; Liu, Xiaoqiang
- Abstract
Objective: To investigate the relationship between the expression of tumor suppressor in lung cancer-1 (TSLC1) and clinicopathological characteristics of patients with non-muscle-invasive bladder cancer (NMIBC) and evaluate the prognostic significance of TSLC1. Methods: TSLC1 expression in 241 specimens of NMIBC was examined by immunohistochemistry. The correlation between TSLC1 expression and clinicopathological characteristics was evaluated using the chi-square test. The prognostic significance of TSLC1 was analyzed by univariate, multivariate analysis and Kaplan-Meier survival curves. Results: The total negative rate of TSLC1 expression was 47.3% in NMIBC. Decreased expression of TSLC1 was correlated with a higher clinical stage, higher pathological grade, the number of tumors, lager tumor size, tumor recurrence and progression. TSLC1 expression was an independent risk factor for predicting tumor recurrence (p = 0.005) and progression (p < 0.001). Conclusion: Decreased expression of TSLC1 is correlated with the malignancy of NMIBC tissues and low TSLC1 expression may serve as a predictor for bladder cancer recurrence and progression. © 2015 S. Karger AG, Basel
- Subjects
BLADDER cancer treatment; LUNG cancer; TUMOR suppressor proteins; DISEASE progression; NONMUSCLE actin
- Publication
Urologia Internationalis, 2016, Vol 96, Issue 2, p142
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000438492