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- Title
The Quality of 5-Aminolevulinic Acid-Induced Photodynamic Diagnosis and Transurethral Resection of Bladder Tumors: Does the Urologist Play a Role?
- Authors
Draga, Ronald O.P.; Grimbergen, Matthijs C.M.; Kok, Esther T.; Jonges, Trudy N.; van Swol, Christiaan F.P.; Bosch, Ruud J.L.H.
- Abstract
Introduction: The aim of this study is to evaluate the quality of photodynamic diagnosis (PDD) and transurethral resection of bladder tumors (TURBT) among different urologists. Patients and Methods: The selected data consists of 194 patients, 268 5-aminolevulinic acid (5-ALA)-induced PDD procedures and 934 biopsies. Tumors were resected and biopsies were taken from suspicious areas under guidance of white light endoscopy and 5-ALA-induced fluorescence cystoscopy. The quality of PDD was determined by evaluating the mean number of tumors resected by 5 urologists and, thereafter, assessing the time to recurrence between groups. Results: Urologist 1 took 37% more biopsies (p < 0.001) and diagnosed 42% more tumors (p = 0.005) and 46% more false positives (p < 0.001) from bladders compared to urologists 2, 3, 4 and 5 together. The mean time to bladder cancer recurrence for all recurrences within 0-18 months was 11.0 months for operator 1 and 8.3 months for the other urologists (p = 0.01). Conclusions: The resecting urologist appears to be an important factor for the quality of standard and PDD-assisted TURBT. Learning curve programs may be required with experienced surgeons accompanying those with less experience. Copyright © 2012 S. Karger AG, Basel
- Subjects
BLADDER cancer treatment; AMINOLEVULINIC acid; PHOTOCHEMOTHERAPY; TRANSURETHRAL prostatectomy; UROLOGISTS; ENDOSCOPY; CANCER relapse
- Publication
Urologia Internationalis, 2012, Vol 89, Issue 3, p326
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000341897