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- Title
Immunohistochemical Study of CA19-9 and SPan-1 in Cases of Hydronephrosis.
- Authors
Inayama, Yoshiaki; Uesato, Masashi; Takase, Kazunori; Motono, Norio; Nakatani, Yukio; Kitamura, Hitoshi
- Abstract
Although the serum level of carbohydrate antigen (CA) 19-9 is reportedly increased in patients with hydronephrosis, virtually no immunohistochemical studies of this condition have been performed. Therefore, we examined immunohistochemically 11 hydronephrotic kidneys and 3 normal control kidneys using antibodies against CA19-9 and SPan-1 another sialylated carbohydrate antigen. Immunoreactivity for CA19-9 was seen in the transitional and tubular epithelia in most of the hydronephrotic kidneys (9 of the 11 cases), and also detected in 2 of the 3 control specimens, although there the distribution appeared to be limited. SPan-1 immunoreactivity showed the same trend. CA19-9 and SPan-1 immunoreactivity in hydronephrosis appeared to be more widely distributed than in controls, although its mechanism remains unclear. Copyright © 1996 S. Karger AG, Basel
- Publication
Urologia Internationalis, 1996, Vol 57, Issue 2, p93
- ISSN
0042-1138
- Publication type
Article
- DOI
10.1159/000282887