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- Title
Assembly and function of RNA silencing complexes.
- Authors
Sontheimer, Erik J.
- Abstract
In the RNA-interference pathway, double-stranded RNA induces sequence-specific mRNA degradation through the action of the RNA-induced silencing complex (RISC). Recent work has provided our first glimpses of the RISC-assembly pathway and uncovered the biochemical roles of critical RISC components. These advances have taken our mechanistic understanding of RNA interference to a new level and promise to improve our ability to exploit this biological process for use in experimental biology and medicine.
- Subjects
RNA; MESSENGER RNA; BIOCHEMISTRY; MOLECULAR biology; GENE silencing
- Publication
Nature Reviews Molecular Cell Biology, 2005, Vol 6, Issue 2, p127
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm1568