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- Title
The many functions of smc proteins in chromosome dynamics.
- Authors
Jessberger, Rolf
- Abstract
Members of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.
- Subjects
CHROMOSOMES; SMC proteins
- Publication
Nature Reviews Molecular Cell Biology, 2002, Vol 3, Issue 10, p767
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm930