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- Title
Multifunctional roles for MALT1 in T-cell activation.
- Authors
Thome, Margot
- Abstract
The activation of T cells is vital to the successful elimination of pathogens, but can also have a deleterious role in autoimmunity and transplant rejection. Various signalling pathways are triggered by the T-cell receptor; these have key roles in the control of the T-cell response and represent interesting targets for therapeutic immunomodulation. Recent findings define MALT1 (mucosa-associated-lymphoid-tissue lymphoma-translocation gene 1) as a protein with proteolytic activity that controls T-cell activation by regulating key molecules in T-cell-receptor-induced signalling pathways.
- Subjects
T cells; AUTOIMMUNITY; CELLULAR mechanics; CELL physiology; STRUCTURE-activity relationships in cell receptors; AUTOANTIBODY analysis; PROTEIN metabolism; ANIMAL experimentation; B cell lymphoma; CARRIER proteins; CELL receptors; CELLULAR signal transduction; COMPARATIVE studies; IMMUNOLOGY technique; RESEARCH methodology; MEDICAL cooperation; MICE; PROTEINS; PROTEOLYTIC enzymes; RESEARCH; DNA-binding proteins; EVALUATION research
- Publication
Nature Reviews Immunology, 2008, Vol 8, Issue 7, p495
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri2338