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- Title
Generating Organic Compounds by Retrosynthetic Pathway via Typical Corey's Synthesis.
- Authors
Ononiwu, Chinonso Godwin; Enwereuzo, Onyekachi Oluchi; Akakuru, Obinna Chigoziem; Ejiogu, Chukwudima Benaiah; Onumah, Chinonso Uchenna; Achukee, Chinedu Kingsley; Umaefulam, Tobechukwu Nnamdi; Abaekwume, Nkechi Nancy; Akakuru, Ozioma Udochukwu
- Abstract
Several methods exist for the synthesis of alkanes including Corey's synthesis, Wurtz reaction, reduction of alcohols and aldehydes, Kolbe's electrolysis, hydrogenation of alkenes, and Grignard reaction. Among the available methods, the age-long Corey's synthesis presents robust advantages of yielding symmetrical, unsymmetrical, straight chain and branched chain alkanes. Moreover, it allows of generating high yields of alkanes by utilizing primary alkyl halide and an array of lithium dialkyl copper ranging from primary, secondary to tertiary. Corey's synthesis has also been implicated in the synthesis of various organic compounds such as (+)-taylorione, terminal alkynes, caribenol A, ketones, and aldehydes. In this work, an explanation of the general concept in the Corey's synthesis is provided. Furthermore, specific examples of Corey's reactions and modifications are discussed. Finally, an outlook into the benefits of the Corey's synthesis in present-day organic synthesis is provided, which is expected to enhance the understanding of organic reaction mechanisms for the development of various organic compounds as drugs for treating diseases.
- Subjects
ORGANIC synthesis; HYDROGENATION; GRIGNARD reagents; ELECTROLYSIS kinetics; HALOALKANES
- Publication
World News of Natural Sciences (WNOFNS), 2021, Vol 36, p88
- ISSN
2543-5426
- Publication type
Article